{"id":48,"date":"2021-08-24T15:27:03","date_gmt":"2021-08-24T15:27:03","guid":{"rendered":"https:\/\/research.unl.edu\/annualreport\/2021\/?p=48"},"modified":"2021-10-21T13:57:44","modified_gmt":"2021-10-21T13:57:44","slug":"penguins","status":"publish","type":"post","link":"https:\/\/research.unl.edu\/annualreport\/2021\/penguins\/","title":{"rendered":"Penguin Hemoglobin Evolved to Meet Oxygen Demands"},"content":{"rendered":"\n

Penguins are deep divers that can hold their breath for up to 30 minutes, giving them time to hunt for dinner. This ability is thanks, in part, to their distinctive hemoglobin, the body\u2019s oxygen courier that travels via the bloodstream.<\/p>\n\n\n\n

Nebraska biologists uncovered hemoglobin\u2019s evolutionary trick that turned penguins into underwater specialists.<\/p>\n\n\n\n

Jay Storz, Willa Cather Professor of Biological Sciences, and his team compared two reconstructed ancient hemoglobin proteins. One protein dates back roughly 60 million years to penguins\u2019 nondiving ancestor. The other protein dates to 20 million years ago, after penguins branched from albatrosses and other flying seabirds and evolved the ability to dive.<\/p>\n\n\n\n

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Jay Storz and postdoctoral researcher Anthony Signore<\/figcaption><\/figure>\n\n\n\n

By identifying differences between the hemoglobins of early penguins and the nondiving penguin ancestor, Storz\u2019s team discovered evolutionary changes that occurred to accommodate long dives.<\/p>\n\n\n\n

Researchers found that penguin hemoglobin evolved to better capture oxygen molecules in the lungs. At the same time, its greater sensitivity to acidic conditions, which occur during the physical strain of diving, induces hemoglobin to release oxygen at its destination.<\/p>\n\n\n\n

This combination allows penguins to maximize the oxygen circulating in the body while they\u2019re under water.<\/p>\n\n\n\n

Although the premise of comparing ancient hemoglobins was straightforward, resurrecting the proteins was not. Storz\u2019s team used a computer model to extrapolate ancient genetic sequences based on differences in the genetic codes among modern penguin species as well as with distantly related seabirds. The idea is similar to comparing differences in related modern languages to trace word origins.<\/p>\n\n\n\n

The team genetically engineered E. coli bacteria to produce the resulting hemoglobins for experimental comparison.<\/p>\n\n\n\n