{"id":84,"date":"2018-10-09T20:40:22","date_gmt":"2018-10-09T20:40:22","guid":{"rendered":"http:\/\/research.unl.edu\/annualreport\/2018\/?p=84"},"modified":"2018-10-30T13:40:24","modified_gmt":"2018-10-30T13:40:24","slug":"enhancing-nonviral-gene-therapy","status":"publish","type":"post","link":"https:\/\/research.unl.edu\/annualreport\/2018\/enhancing-nonviral-gene-therapy\/","title":{"rendered":"Enhancing Nonviral Gene Therapy"},"content":{"rendered":"\n<p>Most gene therapies, a long-sought method for treating numerous medical conditions, have yet to achieve both safety and effectiveness. Nebraska biomedical engineer Angela Pannier\u2019s novel research is finding ways to overcome the technique\u2019s significant hurdles.<\/p>\n\n\n\n<p>For her achievements, Pannier received a 2017 National Institutes of Health Director\u2019s New Innovator Award, an honor that supports exceptionally creative early-career researchers with the potential to transform their fields. She\u2019s the university\u2019s first researcher to earn this prestigious award. <\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1600\" height=\"812\" src=\"http:\/\/research.unl.edu\/annualreport\/2018\/wp-content\/uploads\/2018\/10\/170901_Pannier_014-e1540906400223.jpg\" alt=\"\" class=\"wp-image-85\" srcset=\"https:\/\/research.unl.edu\/annualreport\/2018\/wp-content\/uploads\/2018\/10\/170901_Pannier_014-e1540906400223.jpg 1600w, https:\/\/research.unl.edu\/annualreport\/2018\/wp-content\/uploads\/2018\/10\/170901_Pannier_014-e1540906400223-300x152.jpg 300w, https:\/\/research.unl.edu\/annualreport\/2018\/wp-content\/uploads\/2018\/10\/170901_Pannier_014-e1540906400223-768x390.jpg 768w, https:\/\/research.unl.edu\/annualreport\/2018\/wp-content\/uploads\/2018\/10\/170901_Pannier_014-e1540906400223-1024x520.jpg 1024w, https:\/\/research.unl.edu\/annualreport\/2018\/wp-content\/uploads\/2018\/10\/170901_Pannier_014-e1540906400223-1200x609.jpg 1200w\" sizes=\"auto, (max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 1362px) 62vw, 840px\" \/><figcaption>Angie Pannier<\/figcaption><\/figure>\n\n\n\n<p>Gene therapy introduces genetic material into patients\u2019 cells, often via viruses, to treat disease. Pannier, professor of biological systems engineering, researches ways to promote gene uptake using safer, nonviral methods.<\/p>\n\n\n\n<p>She\u2019s already had success, discovering that a common steroid drug markedly improved nonviral gene uptake. The five-year, nearly $2.2 million NIH award allows her to ramp up her search for other beneficial drugs. <\/p>\n\n\n\n<p>Pannier\u2019s team and Nebraska collaborator Tadeusz Wysocki, professor of electrical and computer engineering, are working to understand the biological mechanisms of gene delivery through mathematical modeling to further improve delivery strategies for gene therapy. <\/p>\n\n\n\n<p>\u201cWe\u2019ll be able to understand the system on a much bigger scale and move forward into applications,\u201d Pannier said.<\/p>\n\n\n\n<p><br\/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Most gene therapies, a long-sought method for treating numerous medical conditions, have yet to achieve both safety and effectiveness. Nebraska biomedical engineer Angela Pannier\u2019s novel research is finding ways to overcome the technique\u2019s significant hurdles. For her achievements, Pannier received a 2017 National Institutes of Health Director\u2019s New Innovator Award, an honor that supports exceptionally [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4],"tags":[116,142,112,96,40,111,99,113,117,110],"class_list":["post-84","post","type-post","status-publish","format-standard","hentry","category-biomedicine-and-human-health","tag-angela-pannier","tag-biological-sciences","tag-biomedical-engineering","tag-biomedicine-and-human-health","tag-engineering","tag-gene-therapy","tag-health","tag-national-institutes-of-health-directors-new-innovator-award","tag-tadeusz-wysocki","tag-virology"],"acf":[],"_links":{"self":[{"href":"https:\/\/research.unl.edu\/annualreport\/2018\/wp-json\/wp\/v2\/posts\/84","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.unl.edu\/annualreport\/2018\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/research.unl.edu\/annualreport\/2018\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/research.unl.edu\/annualreport\/2018\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/research.unl.edu\/annualreport\/2018\/wp-json\/wp\/v2\/comments?post=84"}],"version-history":[{"count":4,"href":"https:\/\/research.unl.edu\/annualreport\/2018\/wp-json\/wp\/v2\/posts\/84\/revisions"}],"predecessor-version":[{"id":429,"href":"https:\/\/research.unl.edu\/annualreport\/2018\/wp-json\/wp\/v2\/posts\/84\/revisions\/429"}],"wp:attachment":[{"href":"https:\/\/research.unl.edu\/annualreport\/2018\/wp-json\/wp\/v2\/media?parent=84"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/research.unl.edu\/annualreport\/2018\/wp-json\/wp\/v2\/categories?post=84"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/research.unl.edu\/annualreport\/2018\/wp-json\/wp\/v2\/tags?post=84"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}