{"id":1082,"date":"2013-10-15T17:56:59","date_gmt":"2013-10-15T17:56:59","guid":{"rendered":"http:\/\/research.unl.edu\/annualreport\/2013\/?p=1082"},"modified":"2013-10-25T13:59:32","modified_gmt":"2013-10-25T13:59:32","slug":"good-or-bad-mutation-it-depends","status":"publish","type":"post","link":"https:\/\/research.unl.edu\/annualreport\/2013\/good-or-bad-mutation-it-depends\/","title":{"rendered":"Good or Bad Mutation \u2013 It Depends"},"content":{"rendered":"

A genetic mutation\u2019s reproductive survival was traditionally thought to depend on whether its effect was good, bad or inconsequential. However, UNL research published in Science<\/em> <\/a>shows the dichotomy between \u201cgood\u201d mutations and \u201cbad\u201d may be more complicated than once thought. Evolutionary biologist Jay Storz and colleagues at UNL and Aarhus University, Denmark, found that whether a given mutation is good or bad often is determined by other mutations associated with it. Studying genetic variation in the hemoglobin protein in deer mice populations from different elevations, they found certain individual mutations that increased hemoglobin\u2019s binding affinity for oxygen in some mutational combinations, but decreased it in others. Because these mutations have context-dependent effects, the order in which mutations occur can determine which pathways evolution is more likely to follow, said Storz, Susan J. Rosowski Professor of Biological Sciences. The National Institutes of Health\u2019s National Heart, Lung and Blood Institute and the National Science Foundation funded this research.<\/p>\n","protected":false},"excerpt":{"rendered":"

A genetic mutation\u2019s reproductive survival was traditionally thought to depend on whether its effect was good, bad or inconsequential. However, UNL research published in Science shows the dichotomy between \u201cgood\u201d mutations and \u201cbad\u201d may be more complicated than once thought. … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":5,"featured_media":1211,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[443],"tags":[550,549,97,40,414],"class_list":["post-1082","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-highlights","tag-genetic-mutation","tag-jay-storz","tag-national-institutes-of-health","tag-national-science-foundation","tag-science"],"acf":[],"_links":{"self":[{"href":"https:\/\/research.unl.edu\/annualreport\/2013\/wp-json\/wp\/v2\/posts\/1082","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.unl.edu\/annualreport\/2013\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/research.unl.edu\/annualreport\/2013\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/research.unl.edu\/annualreport\/2013\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/research.unl.edu\/annualreport\/2013\/wp-json\/wp\/v2\/comments?post=1082"}],"version-history":[{"count":4,"href":"https:\/\/research.unl.edu\/annualreport\/2013\/wp-json\/wp\/v2\/posts\/1082\/revisions"}],"predecessor-version":[{"id":1365,"href":"https:\/\/research.unl.edu\/annualreport\/2013\/wp-json\/wp\/v2\/posts\/1082\/revisions\/1365"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/research.unl.edu\/annualreport\/2013\/wp-json\/wp\/v2\/media\/1211"}],"wp:attachment":[{"href":"https:\/\/research.unl.edu\/annualreport\/2013\/wp-json\/wp\/v2\/media?parent=1082"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/research.unl.edu\/annualreport\/2013\/wp-json\/wp\/v2\/categories?post=1082"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/research.unl.edu\/annualreport\/2013\/wp-json\/wp\/v2\/tags?post=1082"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}